Chemical Property of 4-(Dimethylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Chemical Property:
- Melting Point:161℃
- Refractive Index:1.558
- PSA：81.67000
- Density:1.137 g/cm3
- LogP:2.72010
- Storage Temp.:2-8°C
- Sensitive.:Light Sensitive
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:1.7
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:9
- Exact Mass:307.18959167
- Heavy Atom Count:22
- Complexity:340
- Purity/Quality:
-
97% *data from raw suppliers
M344 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO
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Uses
Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs. M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).
