2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)propanamide

Base Information

• Chemical Name: 2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)propanamide
• CAS No.: 381689-27-6
• Molecular Formula: C₁₇H₁₉N₅OS
• Molecular Weight: 341.437
• Mol file: 381689-27-6.mol

Synonyms:2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-N-p-tolyl-propionamide

Chemical Property of 2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)propanamide

There total 2 articles about 2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.9%

p-toluidine (106-49-0,12221-03-3) + 2-[(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]propanoic acid (381689-39-0) → 2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-N-p-tolyl-propionamide (381689-27-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1002/hc.1075

Reference yield:

5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol (51646-17-4) → 2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-N-p-tolyl-propionamide (381689-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOH / H₂O / 0.5 h / Heating

1.2: 91 percent / H₂O / 5 h / Heating

2.1: 77.9 percent / DCC / dimethylformamide / 6 h / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide;

DOI:10.1002/hc.1075

Reference yield: 70.2%

2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-N-p-tolyl-propionamide (381689-27-6) → 2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonyl)-N-p-tolyl-propionamide

Guidance literature:

With sodium tungstate; dihydrogen peroxide; In water; acetic acid; at 55 - 60 ℃; for 5h;

DOI:10.1002/hc.1075

upstream raw materials:

p-toluidine

2-[(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]propanoic acid

5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol