tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate

Base Information

Chemical Name:tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate
CAS No.:1187648-24-3
Molecular Formula:C₁₉H₂₃ClN₄O₄
Molecular Weight:406.869
Hs Code.:

Synonyms:tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate

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Technology Process of tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate

There total 2 articles about tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3588-56-5
N-[(phenylmethoxy)carbonyl]-D-aspartic acid,1,1-dimethylethyl ester

: 1187648-24-3
tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid; ammonium peroxydisulfate; silver nitrate / water / 75 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; caesium carbonate / 1,4-dioxane / 90 °C

3: hydrogen; palladium on activated charcoal / methanol

With ammonium peroxydisulfate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; palladium on activated charcoal; hydrogen; caesium carbonate; silver nitrate; trifluoroacetic acid; In 1,4-dioxane; methanol; water; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2018.02.049

Reference yield:

: C₁₉H₂₁Cl₂N₃O₄

: 1187648-24-3
tert-butyl 3-amino-3-(3-chloro-6-(4-(methoxycarbonylamino)phenyl)pyridazin-4-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; caesium carbonate / 1,4-dioxane / 90 °C

2: hydrogen; palladium on activated charcoal / methanol

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; palladium on activated charcoal; hydrogen; caesium carbonate; In 1,4-dioxane; methanol; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2018.02.049