methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate

Base Information

Chemical Name:methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate
CAS No.:98127-01-6
Molecular Formula:C₁₄H₂₄O₃Si
Molecular Weight:268.428
Hs Code.:

Synonyms:methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate

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Chemical Property of methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate

Chemical Property:

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Technology Process of methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate

There total 2 articles about methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41309-43-7
(2-bromovinyl)trimethylsilane

: 86891-79-4
methyl 3-methyl-1-oxo-2-cyclohexene-2-carboxylate

: 98127-01-6
methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate

Guidance literature:: With copper(l) iodide; tert.-butyl lithium; Yield given. Multistep reaction;
DOI:10.1021/jo00221a027

Reference yield:

: 3128-06-1
5-ketohexanoic acid

: 98127-01-6
methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / SOCl₂ / benzene / 10 h / Heating

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 4 h, b) 25 deg C, 8 h

3: 1.) t-butyllithium, 2.) CuI

With copper(l) iodide; thionyl chloride; tert.-butyl lithium; lithium diisopropyl amide; In benzene;
DOI:10.1021/jo00221a027

Reference yield:

: 98127-01-6
methyl 2-methyl-6-oxo-2-<(E)-2-(trimethylsilyl)vinyl>cyclohexanecarboxylate

: 98127-03-8
methyl 2,6-dimethyl-6-<(E)-2-(trimethylsilyl)vinyl>-1-cyclohexene-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) ether, 10 min, 2.) ether, 2 h

2: 1.) CuI / 1.) ether, -20 deg C, 2.) ether, -20 deg C, 3 h

With copper(l) iodide; sodium hydride;
DOI:10.1021/jo00221a027