Technology Process of 2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone
There total 2 articles about 2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 4-methoxybenzoate; 2-((fluoromethyl)sulfonyl)pyridine;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ja301601b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
1.2: 11 h
2.1: sodium periodate; rhodium(III) chloride hydrate / tetrachloromethane; water; acetonitrile
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
With
sodium periodate; rhodium(III) chloride hydrate; sodium hydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja301601b
- Guidance literature:
-
methyl 4-iodobenzoate; 2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone;
With
copper(I) thiophene-2-carboxylate; sodium hydrogencarbonate;
In
dimethyl sulfoxide;
at 80 ℃;
for 20h;
With
methanol;
In
dimethyl sulfoxide;
at 80 ℃;
for 1h;
DOI:10.1021/cs4000574
