(S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid

Base Information

Chemical Name:(S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid
CAS No.:219967-73-4
Molecular Formula:C₂₆H₂₅NO₄
Molecular Weight:415.489
Hs Code.:

Synonyms:(S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid

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Chemical Property of (S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid

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Technology Process of (S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid

There total 6 articles about (S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 219967-72-3
(S)-2-(aminomethyl)-4-phenylbutanoic acid

: 219967-73-4
(S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid

Guidance literature:: With sodium carbonate; In acetone; for 2h;
DOI:10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5

Reference yield:

: 170450-83-6
(R)-4-benzyl-3-(4-phenyl-1-oxobutyl)-1,3-oxazolidin-2-one

: 219967-73-4
(S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) TiCl₄, Et₃N / 1.) CH₂Cl₂, 45 min, - 5 deg C; 2.) CH₂Cl₂, 0 deg C, 3 h

2: 70 percent / 30 percent aq. H₂O₂, LiOH*H₂O / tetrahydrofuran; H₂O / 1.5 h / 0 °C

3: 63 percent / H₂ / 10 percent Pd/C / ethanol / 3 h

4: 75 percent / aq. Na₂CO₃ / acetone / 2 h

With lithium hydroxide; hydrogen; dihydrogen peroxide; titanium tetrachloride; sodium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetone;
DOI:10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5

Reference yield:

: 1821-12-1
4-Phenylbutyric acid

: 219967-73-4
(S)-2-<(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)methyl>-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / tetrahydrofuran / 1 h / 0 °C

2: 65 percent / DMAP, Et₃N / tetrahydrofuran / 12 h / Ambient temperature

3: 1.) TiCl₄, Et₃N / 1.) CH₂Cl₂, 45 min, - 5 deg C; 2.) CH₂Cl₂, 0 deg C, 3 h

4: 70 percent / 30 percent aq. H₂O₂, LiOH*H₂O / tetrahydrofuran; H₂O / 1.5 h / 0 °C

5: 63 percent / H₂ / 10 percent Pd/C / ethanol / 3 h

6: 75 percent / aq. Na₂CO₃ / acetone / 2 h

With dmap; lithium hydroxide; hydrogen; dihydrogen peroxide; titanium tetrachloride; sodium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetone;
DOI:10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5