4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester

Base Information

Chemical Name:4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester
CAS No.:223587-46-0
Molecular Formula:C₂₅H₃₀N₂O₆
Molecular Weight:454.523
Hs Code.:

4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid <i>tert</i>-butyl ester

Synonyms:4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester

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Chemical Property of 4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester

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Technology Process of 4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester

There total 1 articles about 4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 65276-90-6
2-nitro-4-(tert-butoxycarbonyl)benzyl bromide

: 4-phenethylaminocrotonate

: 223587-46-0
4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1021/jm980166z

Reference yield:

: 223587-46-0
4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester

: 3-amino-4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-benzoic acid tert-butyl ester

Guidance literature:: With iron; acetic acid; In ethanol; for 16h; Ambient temperature;
DOI:10.1021/jm980166z

Reference yield:

: 223587-46-0
4-{[(3-methoxycarbonyl-allyl)-phenethyl-amino]-methyl}-3-nitro-benzoic acid tert-butyl ester

: (8-chlorocarbonyl-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Fe, AcOH / ethanol / 16 h / Ambient temperature

2: methanol / 72 h / Heating

3: TFA / CH₂Cl₂ / 0.75 h / Ambient temperature

4: SOCl₂ / 0.25 h / Heating

With thionyl chloride; iron; acetic acid; trifluoroacetic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm980166z