4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol

Base Information

Chemical Name:4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol
CAS No.:1310328-31-4
Molecular Formula:C₁₉H₁₈O₄
Molecular Weight:310.35
Hs Code.:

Synonyms:4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol

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Technology Process of 4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol

There total 11 articles about 4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1310328-62-1
2-{6-[4-(tert-butyldimethylsilanyloxy)phenyl]-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl}-propan-2-ol

: 1310328-31-4
4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol

Guidance literature:: With pyridine; pyridine hydrofluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2011.03.022

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1310328-31-4
4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; acetonitrile / 16 h

2: triphenylphosphine / dichloromethane / 0.5 h / 0 - 20 °C

3: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / -78 °C

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 20 h / 85 °C / Inert atmosphere

5: pyridine; pyridine hydrofluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; pyridine hydrofluoride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.03.022

Reference yield:

: 4806-05-7
2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-6-ol

: 1310328-31-4
4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol

Guidance literature:: Multi-step reaction with 3 steps

1: Iodine monochloride; acetic acid / 3 h

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 20 h / 85 °C / Inert atmosphere

3: pyridine; pyridine hydrofluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; pyridine hydrofluoride; Iodine monochloride; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.ejmech.2011.03.022