9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate

Base Information

• Chemical Name: 9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate
• CAS No.: 348636-02-2
• Molecular Formula: C₁₉H₂₂N₄O₅
• Molecular Weight: 386.407
• Mol file: 348636-02-2.mol

Synonyms:9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate

Chemical Property of 9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate

There total 5 articles about 9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Methyl (E)-4-[benzyl(5-formyl-2,6-dimethoxypyrimidin-4-yl)amino]but-2-enoate (212131-74-3) → Methyl 2-(1-benzyl-8-formyl-7-methoxy-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-3-yl)acetate + 9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate (348636-02-2) + Methyl 2-(1-benzyl-8-hydroxyiminomethyl-7-methoxy-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-3-yl)acetate + Methyl 5-benzyl-7,9-dimethoxy-1,3,3a,4,5,9b-hexahydroisoxazolo[3',4':4,5]pyrido[2,3-d]pyrimidine-3-carboxylate

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In methanol; at 0 ℃; for 36h;

DOI:10.1039/b007163n

Reference yield:

methyl-4-bromo-2-butenoate (1117-71-1,56699-18-4,6000-00-6) → 9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate (348636-02-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / diethyl ether / 24 h / 0 °C

2: 78 percent / Et₃N / CHCl₃ / 10 h / 20 °C

3: 65 percent / NH₂OH*HCl; pyridine / methanol / 36 h / 0 °C

With pyridine; hydroxylamine hydrochloride; triethylamine; In methanol; diethyl ether; chloroform;

DOI:10.1039/b007163n

Reference yield:

(E)-methyl-4-(N-benzylamino)-but-2-enoate (131489-59-3) → 9-Benzyl-2,4-dimethoxy-7-(2-methoxy-2-oxoethyl)-8,9-dihydro-7H-pyrimido[4,5-e][1,4]diazepin-6-ium-6-olate (348636-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / Et₃N / CHCl₃ / 10 h / 20 °C

2: 65 percent / NH₂OH*HCl; pyridine / methanol / 36 h / 0 °C

With pyridine; hydroxylamine hydrochloride; triethylamine; In methanol; chloroform;

DOI:10.1039/b007163n

upstream raw materials:

Methyl (E)-4-[benzyl(5-formyl-2,6-dimethoxypyrimidin-4-yl)amino]but-2-enoate

methyl-4-bromo-2-butenoate

(E)-methyl-4-(N-benzylamino)-but-2-enoate

4-chloro-2,6-dimethoxypyrimidine-5-carboxaldehyde