C₁₉H₁₇BrN₂O₄

Base Information

• Chemical Name: C₁₉H₁₇BrN₂O₄
• CAS No.: 1421615-02-2
• Molecular Formula: C₁₉H₁₇BrN₂O₄
• Molecular Weight: 417.259
• Mol file: 1421615-02-2.mol

Synonyms:C₁₉H₁₇BrN₂O₄

Chemical Property of C₁₉H₁₇BrN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇BrN₂O₄

There total 3 articles about C₁₉H₁₇BrN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromobenzoyl chloride (1711-09-7) + 1-methyl-5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole (1421615-10-2) → C19H17BrN2O4 (1421615-02-2)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.10.031

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → C19H17BrN2O4 (1421615-02-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / diethyl ether / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 12 h / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: hydrazine hydrate / 0.5 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

6.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium hydride; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil; 1.1: |Friedel-Crafts Acylation / 6.1: |Friedel-Crafts Acylation;

DOI:10.1016/j.bmcl.2012.10.031

Reference yield:

3-oxo-3-(2,4,6-trimethoxyphenyl)propanal → C19H17BrN2O4 (1421615-02-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 0.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

3: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium hydride; hydrazine hydrate; In dichloromethane; N,N-dimethyl-formamide; 3: |Friedel-Crafts Acylation;

DOI:10.1016/j.bmcl.2012.10.031

upstream raw materials:

3-bromobenzoyl chloride

1-methyl-5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole

1,2,3-trimethoxybenzene