(-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine

Base Information

Chemical Name:(-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine
CAS No.:1062601-62-0
Molecular Formula:C₁₂H₁₅NO
Molecular Weight:189.257
Hs Code.:

Synonyms:(-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine

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Technology Process of (-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine

There total 8 articles about (-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 868051-83-6
(3R,4S)-1-benzyl-piperidine-3,4-diol

: 1062601-62-0
(-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine

Guidance literature:: (3R,4S)-1-benzyl-piperidine-3,4-diol; With 2-acetoxy-2-methylpropanoyl chloride; In dichloromethane; at 20 ℃; for 2.16667h; Inert atmosphere;

With water; potassium carbonate; In methanol; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c2ob25411e

Reference yield:

: 725715-12-8
3-(phenylmethyl)-7-oxa-3-azabicyclo[4.1.0]heptane

: 1062601-62-0
(-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine

: 1384733-07-6
C₁₂H₁₅NO

Guidance literature:: With Curvularia lunata; In dimethyl sulfoxide; at 28 ℃; for 120h; optical yield given as %ee; enantioselective reaction; Resolution of racemate;
DOI:10.1039/c2ob25411e

Reference yield:

: 1384732-93-7
C₁₅H₂₁NO₂

: 1062601-62-0
(-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.1: 2-acetoxy-2-methylpropanoyl chloride / dichloromethane / 2.17 h / 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; 2-acetoxy-2-methylpropanoyl chloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c2ob25411e