2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

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Chemical Name:2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid
CAS No.:1613317-15-9
Molecular Formula:C₂₇H₃₀N₂O₄S
Molecular Weight:478.612
Hs Code.:

Synonyms:2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

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Chemical Property of 2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

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Technology Process of 2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

There total 11 articles about 2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1613317-31-9
7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-ylamine

: 5962-96-9
2-Cyclohexylbutandisaeure-anhydrid

: 1613317-15-9
2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

Guidance literature:: In chloroform; at 65 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1613219-68-3
7-bromonaphthalene-2-carboxylic acid amide

: 1613317-15-9
2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / tetrahydrofuran / 50 °C / Inert atmosphere

2: ethanol / 48 h / 90 °C / Inert atmosphere

3: benzophenoneimine; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium t-butanolate / toluene / 90 °C / Inert atmosphere

4: chloroform / 0.5 h / 65 °C / Inert atmosphere

With Lawessons reagent; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; benzophenoneimine; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; ethanol; chloroform; toluene;

Reference yield:

: 5043-14-1
7-bromonaphthalene-2-carboxylic acid

: 1613317-15-9
2-cyclohexyl-N-{7-[4-(tetrahydrofuran-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

2: ammonium hydroxide / diethyl ether / 1 h / 20 °C / Inert atmosphere

3: Lawessons reagent / tetrahydrofuran / 50 °C / Inert atmosphere

4: ethanol / 48 h / 90 °C / Inert atmosphere

5: benzophenoneimine; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium t-butanolate / toluene / 90 °C / Inert atmosphere

6: chloroform / 0.5 h / 65 °C / Inert atmosphere

With Lawessons reagent; ammonium hydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; oxalyl dichloride; benzophenoneimine; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N,N-dimethyl-formamide; sodium t-butanolate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; toluene;