ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate

Base Information

Chemical Name:ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate
CAS No.:1170694-13-9
Molecular Formula:C₁₇H₁₆BrNO₄
Molecular Weight:378.222
Hs Code.:

Synonyms:ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate

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Chemical Property of ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate

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Technology Process of ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate

There total 3 articles about ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1170694-12-8
ethyl 3-(2-bromophenyl)but-3-enoyl(furan-2-yl)carbamate

: 1170694-13-9
ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate

Guidance literature:: In toluene; at 150 ℃;
DOI:10.1016/j.tetlet.2008.12.088

Reference yield:

: 3-(2-bromophenyl)but-3-enoic acid

: 1170694-13-9
ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

1.2: 0.08 h / 0 °C / Inert atmosphere

2.1: toluene / 10 h / 150 °C / Inert atmosphere; Sealed tube

With n-butyllithium; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/acs.joc.6b00771

Reference yield:

: 3-(2-bromophenyl)but-3-en-1-ol

: 1170694-13-9
ethyl 3a-(2-bromophenyl)-2,5-dioxo-2,3,3a,4,5,6-hexahydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Jones reagent / acetone / 2 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

2.2: 0.08 h / 0 °C / Inert atmosphere

3.1: toluene / 10 h / 150 °C / Inert atmosphere; Sealed tube

With Jones reagent; n-butyllithium; In tetrahydrofuran; hexane; acetone; toluene;
DOI:10.1021/acs.joc.6b00771