3-(dimethylamino)-2-nitrobenzyl bromide

Base Information

• Chemical Name: 3-(dimethylamino)-2-nitrobenzyl bromide
• CAS No.: 149155-80-6
• Molecular Formula: C₉H₁₁BrN₂O₂
• Molecular Weight: 259.103
• Mol file: 149155-80-6.mol

Synonyms:3-(dimethylamino)-2-nitrobenzyl bromide

Chemical Property of 3-(dimethylamino)-2-nitrobenzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-(dimethylamino)-2-nitrobenzyl bromide

There total 3 articles about 3-(dimethylamino)-2-nitrobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

3-(dimethylamino)-2-nitrobenzyl alcohol (149155-79-3) → 3-(dimethylamino)-2-nitrobenzyl bromide (149155-80-6)

Guidance literature:

With phosphorus tribromide; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1021/jm00063a013

Reference yield:

3-chloro-2-nitro-benzoic acid (4771-47-5) → 3-(dimethylamino)-2-nitrobenzyl bromide (149155-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / B₂H₆ / tetrahydrofuran / 2 h / Ambient temperature

2: 76 percent / H₂O; dimethylformamide / 4 h / 120 °C

3: 49 percent / PBr₃ / dimethylformamide / 1 h / Ambient temperature

With phosphorus tribromide; diborane; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00063a013

Reference yield:

(3-chloro-2-nitrophenyl)methanol (77158-86-2) → 3-(dimethylamino)-2-nitrobenzyl bromide (149155-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / H₂O; dimethylformamide / 4 h / 120 °C

2: 49 percent / PBr₃ / dimethylformamide / 1 h / Ambient temperature

With phosphorus tribromide; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm00063a013

upstream raw materials:

3-(dimethylamino)-2-nitrobenzyl alcohol

3-chloro-2-nitro-benzoic acid

(3-chloro-2-nitrophenyl)methanol

Downstream raw materials:

3-<4-(5-methyl-4-phenyl-1H-imidazol-1-yl)-1-butenyl>-2-nitro-N,N-dimethylaniline