C₁₈H₁₈F₆NP

Base Information

• Chemical Name: C₁₈H₁₈F₆NP
• CAS No.: 13792-88-6
• Molecular Formula: C₁₈H₁₈F₆NP
• Molecular Weight: 393.312
• Mol file: 13792-88-6.mol

Synonyms:C₁₈H₁₈F₆NP

Chemical Property of C₁₈H₁₈F₆NP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₈H₁₈F₆NP

There total 1 articles about C₁₈H₁₈F₆NP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

3-bromo-1-trifluoromethylbenzene (401-78-5) + diethylphosphoramidous dichloride (1069-08-5) → C18H18F6NP (13792-88-6)

Guidance literature:

3-bromo-1-trifluoromethylbenzene; With magnesium; In tetrahydrofuran; at 30 - 40 ℃; Inert atmosphere;

diethylphosphoramidous dichloride; In tetrahydrofuran; at 10 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201404071

Reference yield: 71.6%

C18H18F6NP (13792-88-6) → bis[3-(trifluoromethyl)phenyl]chlorophosphine (13685-25-1)

Guidance literature:

With phosphorus trichloride; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201404071

Reference yield:

C18H18F6NP (13792-88-6) → C19H12F6NP

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus trichloride / 1 h / 90 °C / Inert atmosphere

2.1: TurboGrignard; 1,4-dioxane / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

2.2: 10 °C / Inert atmosphere

With 1,4-dioxane; TurboGrignard; phosphorus trichloride; In tetrahydrofuran;

DOI:10.1002/chem.201404071

upstream raw materials:

3-bromo-1-trifluoromethylbenzene

diethylphosphoramidous dichloride

Downstream raw materials:

bis[3-(trifluoromethyl)phenyl]chlorophosphine