Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate

Base Information

• Chemical Name: Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate
• CAS No.: 291306-82-6
• Molecular Formula: C₂₈H₃₄Cl₂N₂O₆S
• Molecular Weight: 597.56

Synonyms:Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate

Chemical Property of Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate

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Technology Process of Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate

There total 1 articles about Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-6-(iodo)-7-((methylsulphonyl)amino)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291306-58-6) + ethyl acrylate (140-88-5,9003-32-1) → Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate (291306-82-6)

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; for 2.5h; Heating / reflux;

Reference yield:

Ethyl (E)-3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-2-propenoate (291306-82-6) → Ethyl 3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}propanoate (291306-83-7)

Guidance literature:

With toluene-4-sulfonic acid hydrazide; In toluene; for 5h; Heating / reflux;

upstream raw materials:

Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-6-(iodo)-7-((methylsulphonyl)amino)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

ethyl acrylate

Downstream raw materials:

Ethyl 3-{(5S,8S)-5-[(tert-butoxycarbonyl)(methyl)amino]-8-(3,4-dichlorophenyl)-3-[(methylsulphonyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}propanoate

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