4-FLUORO-5-HYDROXYINDOLE

Base Information

• Chemical Name: 4-FLUORO-5-HYDROXYINDOLE
• CAS No.: 288386-04-9
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.14
• Hs Code.: 2933998090
• Mol file: 288386-04-9.mol

Synonyms:4-Fluoro-5-hydroxyindole;

Chemical Property of 4-FLUORO-5-HYDROXYINDOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.7
• Boiling Point: 322.387 °C at 760 mmHg
• Flash Point: 148.775 °C
• PSA: 36.02000
• Density: 1.446 g/cm³
• LogP: 2.01260
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluoro-1H-indol-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-5-HYDROXYINDOLE

There total 2 articles about 4-FLUORO-5-HYDROXYINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-fluoro-3-benzyloxy-6-nitrotoluene (1229454-43-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-fluoro-1H-indol-5-ol (288386-04-9)

Guidance literature:

2-fluoro-3-benzyloxy-6-nitrotoluene; N,N-dimethyl-formamide dimethyl acetal; at 180 ℃; for 1h; Microwave irradiation; Sealed vial;

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

→ 4-fluoro-1H-indol-5-ol (288386-04-9)

Guidance literature:

Reference yield:

4-fluoro-1H-indol-5-ol (288386-04-9) → C26H21FN2O5

Guidance literature:

Multi-step reaction with 2 steps

1: Thermotoga maritima pyridoxal phosphate (PLP)-dependent tryptophan B synthase / aq. phosphate buffer / 4 h / 37 °C / pH 7 / Enzymatic reaction

2: sodium hydrogencarbonate / 1,4-dioxane / 20 °C

With Thermotoga maritima pyridoxal phosphate (PLP)-dependent tryptophan B synthase; sodium hydrogencarbonate; In 1,4-dioxane; aq. phosphate buffer;

DOI:10.1039/d1cc00187f

upstream raw materials:

2-fluoro-3-benzyloxy-6-nitrotoluene

N,N-dimethyl-formamide dimethyl acetal

Refernces

• 1、 -. "Quinoline derivatives having vegf inhibiting activity". . . Retrieved 2008/06/13.