2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Base Information

Chemical Name:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
CAS No.:1352064-64-2
Molecular Formula:C₂₆H₃₁Cl₂NO₄
Molecular Weight:492.442
Hs Code.:

Synonyms:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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Chemical Property of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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Technology Process of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

There total 5 articles about 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352064-40-4
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-5-oxohexan-3-yl)piperidin-3-yl)acetic acid

: 1352064-65-3
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5S)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1352064-64-2
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: With methanol; sodium tetrahydroborate; In diethyl ether; at 0 - 20 ℃;

Reference yield:

: 1352076-09-5
(3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S)-5-hydroxyhexan-3-yl)-3-methylpiperidin-2-one

: 1352064-65-3
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5S)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1352064-64-2
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

2: sodium tetrahydroborate / diethyl ether; methanol / 1 h / 0 - 25 °C / Inert atmosphere

With sodium tetrahydroborate; sodium periodate; ruthenium(III) trichloride hydrate; In methanol; tetrachloromethane; diethyl ether; water; acetonitrile;
DOI:10.1021/jm401753e

Reference yield:

: C₂₇H₃₁Cl₂NO₂

: 1352064-65-3
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5S)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1352064-64-2
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((3S,5R)-5-hydroxyhexan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / acetonitrile / 1.5 h / 25 °C / Inert atmosphere

2: tetrahydrofuran; toluene / 3 h / 0 - 25 °C / Inert atmosphere

3: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

4: sodium tetrahydroborate / diethyl ether; methanol / 1 h / 0 - 25 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; ruthenium(III) trichloride hydrate; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; water; toluene; acetonitrile;
DOI:10.1021/jm401753e