4-(2-bromophenyl)-2-phenylbutanal

Base Information

• Chemical Name: 4-(2-bromophenyl)-2-phenylbutanal
• CAS No.: 1092491-73-0
• Molecular Formula: C₁₆H₁₅BrO
• Molecular Weight: 303.198
• Mol file: 1092491-73-0.mol

Synonyms:4-(2-bromophenyl)-2-phenylbutanal

Chemical Property of 4-(2-bromophenyl)-2-phenylbutanal

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(2-bromophenyl)-2-phenylbutanal

There total 1 articles about 4-(2-bromophenyl)-2-phenylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C16H17BrO (1092491-49-0) → 4-(2-bromophenyl)-2-phenylbutanal (1092491-73-0)

Guidance literature:

C₁₆H₁₇BrO; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/anie.200803809

Reference yield: 81.0%

4-(2-bromophenyl)-2-phenylbutanal (1092491-73-0) → (R)-1-phenyl-2,3-dihydro-1H-indene-1-carbaldehyde (1092492-05-1)

Guidance literature:

With (S)-2-(2-(bis(4-methoxyphenyl)phosphino)phenyl)-4-tert-butyl-4,5-dihydrooxazole tetrafluoroborate salt; lead acetate; caesium carbonate; In tert-butyl alcohol; at 80 ℃; for 24h; optical yield given as %ee; Inert atmosphere;

DOI:10.1002/anie.200803809

Reference yield:

4-(2-bromophenyl)-2-phenylbutanal (1092491-73-0) → (R)-1-phenyl-2,3-dihydro-1H-indene-1-carbaldehyde (1092492-05-1) + (S)-1-phenyl-2,3-dihydro-1H-indene-1-carbaldehyde

Guidance literature:

With C₃₆H₃₀NO₂P; palladium diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201108061

upstream raw materials:

C₁₆H₁₇BrO

Downstream raw materials:

(R)-1-phenyl-2,3-dihydro-1H-indene-1-carbaldehyde

Refernces