1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

Base Information

Chemical Name:1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one
CAS No.:510730-22-0
Molecular Formula:C₃₅H₃₄N₂O₄S
Molecular Weight:578.732
Hs Code.:

Synonyms:1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

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Chemical Property of 1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

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Technology Process of 1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

There total 7 articles about 1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 510730-21-9
1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

: 510730-22-0
1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

Guidance literature:: With 4-toluenesulfonyl azide; sodium hydride; In tetrahydrofuran; benzene; at 20 ℃; for 6h;
DOI:10.1021/ja029534l

Reference yield:

: 510730-18-4
1-bromo-2-triphenylmethoxymethyl-2-propene

: 510730-22-0
1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / NaH / tetrahydrofuran / 3 h / 20 °C

2: 3.12 g / Na₂HPO₄; Na-Hg / tetrahydrofuran / 3 h / 20 °C

3: 98 percent / nBuLi / tetrahydrofuran / 1 h / 0 °C

4: 79 percent / NaH; p-toluenesulfonyl azide / benzene; tetrahydrofuran / 6 h / 20 °C

With disodium hydrogenphosphate; n-butyllithium; 4-toluenesulfonyl azide; sodium amalgam; sodium hydride; In tetrahydrofuran; benzene;
DOI:10.1021/ja029534l

Reference yield:

: 131706-44-0
ethyl 2-(triphenylmethoxymethyl)propenoate

: 510730-22-0
1-diazo-1-(2,4,6-trimethylphenylsulfonyl)-5-triphenylmethoxymethyl-5-hexen-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / diisobutylaluminium hydride / CH₂Cl₂ / 1 h / -78 °C

2: 99 percent / CBr₄; PPh₃ / CH₂Cl₂ / 0.5 h / 20 °C

3: 57 percent / NaH / tetrahydrofuran / 3 h / 20 °C

4: 3.12 g / Na₂HPO₄; Na-Hg / tetrahydrofuran / 3 h / 20 °C

5: 98 percent / nBuLi / tetrahydrofuran / 1 h / 0 °C

6: 79 percent / NaH; p-toluenesulfonyl azide / benzene; tetrahydrofuran / 6 h / 20 °C

With disodium hydrogenphosphate; n-butyllithium; 4-toluenesulfonyl azide; sodium amalgam; carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ja029534l