9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile

Base Information

Chemical Name:9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile
CAS No.:1392299-55-6
Molecular Formula:C₂₉H₂₃Br₂N₃
Molecular Weight:573.33
Hs Code.:

Synonyms:9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile

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Chemical Property of 9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile

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Technology Process of 9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile

There total 1 articles about 9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1392299-60-3
6,8-dibromo-3,4-dihydroacridin-1(2H)-one

: 94835-37-7
4-piperidino-3-cyano-2H-pyran-2-one

: 1392299-55-6
9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.4h;
DOI:10.1039/c2jm31052j

Reference yield: 75.0%

: 1392299-55-6
9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile

: 98-80-6
phenylboronic acid

: 1392299-61-4
2-(piperidin-1-yl)-4,9,11-triphenyl-5,6-dihydrobenzo[a]acridine-1-carbonitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.75h; Inert atmosphere;
DOI:10.1039/c2jm31052j

Reference yield:

: 1392299-55-6
9,11-dibromo-4-phenyl-2-(piperidin-1-yl)-5,6-dihydrobenzo[a]acridine-1-carbonitrile

: 98-80-6
phenylboronic acid

: 1392299-62-5
2-(piperidin-1-yl)-4,9,11-triphenyl-benzo[a]acridine-1-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide / 0.75 h / 80 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 1 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In N,N-dimethyl-formamide; benzene; 1: Suzuki coupling;
DOI:10.1039/c2jm31052j