1,2-O-DIOCTADECYL-SN-GLYCEROL

Base Information

• Chemical Name: 1,2-O-DIOCTADECYL-SN-GLYCEROL
• CAS No.: 82188-61-2
• Molecular Formula: C39H80 O3
• Molecular Weight: 597.05
• Mol file: 82188-61-2.mol

Synonyms:1-Propanol,2,3-bis(octadecyloxy)-, (S)-; sn-1,2-dioctadecylglycerol

Chemical Property of 1,2-O-DIOCTADECYL-SN-GLYCEROL

Chemical Property:

• Melting Point: 65-66 °C(Solv: acetone (67-64-1))
• Boiling Point: 653.6±35.0 °C(Predicted)
• PKA: 14.23±0.10(Predicted)
• PSA: 38.69000
• Density: 0.874±0.06 g/cm3(Predicted)
• LogP: 12.90350
• Storage Temp.: -15°C
• Solubility.: Chloroform (Slightly), Pyridine (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1,2-O-Dioctadecyl-sn-glycerol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-O-Dioctadecyl-sn-glycerol is used in the synthesis of vascular endothelial growth factor (vegf) nucleic acid ligand complexes.

Technology Process of 1,2-O-DIOCTADECYL-SN-GLYCEROL

There total 5 articles about 1,2-O-DIOCTADECYL-SN-GLYCEROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,2-di-O-octadecyl-3-O-benzyl-sn-glycerol (13071-58-4) → 1,2-O-dioctadecyl-Sn-glycerol (82188-61-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 12h;

DOI:10.1080/07328309808007460

Reference yield: 72.0%

1,2-di-O-octadecyl-3-O-<2-(trimethylsilyl)ethoxymethyl>-sn-glycerol (114047-21-1) → 1,2-O-dioctadecyl-Sn-glycerol (82188-61-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1246/bcsj.60.2169

Reference yield: 61.0%

1,2-di-O-octadecyl-3-O-(2-methoxyethoxymethyl)-sn-glycerol (114047-20-0) → 1,2-O-dioctadecyl-Sn-glycerol (82188-61-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1246/bcsj.60.2169

upstream raw materials:

1,2-di-O-octadecyl-3-O-benzyl-sn-glycerol

1,2-di-O-octadecyl-3-O-(2-methoxyethoxymethyl)-sn-glycerol

1,2-di-O-octadecyl-3-O-<2-(trimethylsilyl)ethoxymethyl>-sn-glycerol

1-Bromooctadecane

Downstream raw materials:

1,2-di-O-octadecyl-sn-glycerol 3-(2-benzyloxycarbonylaminoethyl)phosphonate

1,2-di-O-octadecyl-sn-glycerol 3-

1,2-di-O-octadecyl-sn-glycerol 3-(3-benzyloxycarbonylaminopropyl)phosphonate

1,2-di-O-octadecyl-sn-glycero-3-phosphatidylcholine

Refernces

• 1、 Figueroa-Perez, Santiago,Verez-Bencomo, Vicente. "Synthesis of neoglycolipids containing oligosaccharides based on 3,6-branched-α-D-mannopyranosides as the carbohydrate moieties". . p. 851 - 868. Retrieved 2007/10/03.