(S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

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Chemical Name:(S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride
CAS No.:128746-07-6
Molecular Formula:C₃₂H₄₃N₅O₆*ClH
Molecular Weight:630.184
Hs Code.:

(S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

Synonyms:(S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

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Chemical Property of (S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

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Technology Process of (S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

There total 5 articles about (S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

: 128719-57-3
N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl-D-tryptophyl-L-leucine methyl ester

: 128746-07-6
(S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 0.75h; Ambient temperature;

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 128746-07-6
(S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 85.9 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

2: 83.6 percent / 6N HCl, dithioethane / ethyl acetate / 1 h

3: 92 percent / Et₃N / dimethylformamide / Ambient temperature

4: 87.8 percent / 3N HCl / ethyl acetate / 0.75 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; ethane-1,2-dithiol; triethylamine; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 128719-24-4
N-tert-butoxycarbonyl-D-tryptophyl-L-leucine methyl ester

: 128746-07-6
(S)-2-[(R)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 83.6 percent / 6N HCl, dithioethane / ethyl acetate / 1 h

2: 92 percent / Et₃N / dimethylformamide / Ambient temperature

3: 87.8 percent / 3N HCl / ethyl acetate / 0.75 h / Ambient temperature

With hydrogenchloride; ethane-1,2-dithiol; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;