(1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine

Base Information

• Chemical Name: (1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine
• CAS No.: 1032325-99-7
• Molecular Formula: C₃₈H₄₇NO₂Si₂
• Molecular Weight: 605.968
• Mol file: 1032325-99-7.mol

Synonyms:(1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine

Chemical Property of (1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine

There total 1 articles about (1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-3-(benzyloxy)-3-(2S,3R,4R,5R)-3-(benzyloxy)-4-[dimethyl(phenyl)silyl]-5-({[dimethyl(phenyl)silyl]methyl}pyrrolidin-2-yl)propan-1-ol (1032325-97-5) → (1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine (1032325-99-7)

Guidance literature:

With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.200701776

Reference yield: 41.0%

(1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine (1032325-99-7) + acetic acid (64-19-7,77671-22-8) → (1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-3-(hydroxymethyl)-1H-pyrrolizin-2-ol-N-oxide (1032326-03-6) + C24H29NO5 (1032326-01-4)

Guidance literature:

(1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-2-[dimethyl(phenyl)silyl]-3-{[dimethyl(phenyl)silyl]methyl}-1H-pyrrolizine; With mercuric triflate; In acetic acid; at 20 ℃; for 1h; Inert atmosphere;

acetic acid; With peracetic acid; at 20 ℃; for 120h; stereospecific reaction;

DOI:10.1002/chem.200701776

upstream raw materials:

(S)-3-(benzyloxy)-3-(2S,3R,4R,5R)-3-(benzyloxy)-4-[dimethyl(phenyl)silyl]-5-({[dimethyl(phenyl)silyl]methyl}pyrrolidin-2-yl)propan-1-ol

Downstream raw materials:

(1R,2R,3R,7S,7aS)-1,7-bis(benzyloxy)hexahydro-3-(hydroxymethyl)-1H-pyrrolizin-2-ol-N-oxide

C₂₄H₂₉NO₅