(4-AMINO-PIPERIDIN-1-YL)-(4-FLUORO-PHENYL)-METHANONE HYDROCHLORIDE

Base Information

• Chemical Name: (4-AMINO-PIPERIDIN-1-YL)-(4-FLUORO-PHENYL)-METHANONE HYDROCHLORIDE
• CAS No.: 139679-50-8
• Molecular Formula: C12H15 F N2 O . Cl H
• Molecular Weight: 258.723
• Hs Code.: 2933399090
• Mol file: 139679-50-8.mol

Synonyms:4-Piperidinamine,1-(4-fluorobenzoyl)-, monohydrochloride (9CI); (4-Aminopiperidin-1-yl)(4-fluorophenyl)methanonehydrochloride

Chemical Property of (4-AMINO-PIPERIDIN-1-YL)-(4-FLUORO-PHENYL)-METHANONE HYDROCHLORIDE

Chemical Property:

• PSA: 46.33000
• LogP: 2.82920

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Fluorobenzoyl)piperidin-4-amine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-AMINO-PIPERIDIN-1-YL)-(4-FLUORO-PHENYL)-METHANONE HYDROCHLORIDE

There total 1 articles about (4-AMINO-PIPERIDIN-1-YL)-(4-FLUORO-PHENYL)-METHANONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-Fluorobenzoyl)-4-piperidinyl]carbamic acid, 2-(trimethylsilyl)ethyl ester (139679-49-5) → 4-amino-N-(4'-fluorobenzoyl)piperidine hydrochloride (139679-50-8)

Guidance literature:

With cesium fluoride; In dimethyl sulfoxide;

Reference yield: 78.0%

4-bromo-2-(trifluoromethyl)benzene-1-sulfonyl chloride (176225-10-8) + 4-amino-N-(4'-fluorobenzoyl)piperidine hydrochloride (139679-50-8) → 4-bromo-N-[1-(4-fluorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide (1027009-20-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

upstream raw materials:

[1-(4-Fluorobenzoyl)-4-piperidinyl]carbamic acid, 2-(trimethylsilyl)ethyl ester

Downstream raw materials:

4-bromo-N-[1-(4-fluorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide

Refernces