benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate
CAS No.:1437682-67-1
Molecular Formula:C₂₂H₃₃NO₃
Molecular Weight:359.509
Hs Code.:

Synonyms:benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate

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Chemical Property of benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate

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Technology Process of benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate

There total 5 articles about benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1437682-63-7
benzyl (2S,5R)-(-)-5-allyl-2-heptanoylpyrrolidine-1-carboxylate

: 1437682-67-1
benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate

Guidance literature:: benzyl (2S,5R)-(-)-5-allyl-2-heptanoylpyrrolidine-1-carboxylate; With cerium(III) chloride heptahydrate; In methanol; at 0 ℃; for 0.166667h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 21h;
DOI:10.1002/ejoc.201200974

Reference yield:

: 1437682-35-3
benzyl (2S,5R)-(-)-5-allyl-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1437682-67-1
benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 h / 0 - 20 °C

2.1: tetrahydrofuran / 24 h / 0 - 20 °C

3.1: pyridinium chlorochromate / dichloromethane / 23 h / 20 °C

4.1: cerium(III) chloride heptahydrate / methanol / 0.17 h / 0 °C

4.2: 21 h / 0 - 20 °C

With cerium(III) chloride heptahydrate; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 4.1: |Luche Cerium Reduction;
DOI:10.1002/ejoc.201200974

Reference yield:

: 123457-52-3
(2S,5R)-5-allylpyrrolidine-1,2-dicarboxylic acid 1-benzylester 2-methylester

: 1437682-67-1
benzyl (2S,2αR,5R)-(+)-5-allyl-2-(1-hydroxyheptyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Super Hydride / tetrahydrofuran / 2 h / 0 °C

2.1: pyridinium chlorochromate / dichloromethane / 20 h / 0 - 20 °C

3.1: tetrahydrofuran / 24 h / 0 - 20 °C

4.1: pyridinium chlorochromate / dichloromethane / 23 h / 20 °C

5.1: cerium(III) chloride heptahydrate / methanol / 0.17 h / 0 °C

5.2: 21 h / 0 - 20 °C

With cerium(III) chloride heptahydrate; Super Hydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 5.1: |Luche Cerium Reduction;
DOI:10.1002/ejoc.201200974