6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide

Base Information

Chemical Name:6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide
CAS No.:1383816-39-4
Molecular Formula:C₂₇H₂₇F₃N₄O₄
Molecular Weight:528.531
Hs Code.:

Synonyms:6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide

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Chemical Property of 6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide

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Technology Process of 6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide

There total 5 articles about 6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383816-96-3
6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinic acid

: 1383816-39-4
6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide

Guidance literature:: With ammonium chloride; N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 4h;

Reference yield:

: (5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)-methanol

: 1383816-39-4
6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 6.5 h / -5 - 25 °C

2: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 0 - 25 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 25 °C

4: caesium carbonate / dimethyl sulfoxide / 4 h / 25 - 80 °C

5: water; sodium hydroxide / tetrahydrofuran; methanol / 4 h / 50 °C

6: ammonium chloride; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C

With hydrogenchloride; 1,2,3-Benzotriazole; thionyl chloride; 18-crown-6 ether; potassium tert-butylate; water; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 4-(chloromethyl)-5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole

: 1383816-39-4
6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 0 - 25 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 25 °C

3: caesium carbonate / dimethyl sulfoxide / 4 h / 25 - 80 °C

4: water; sodium hydroxide / tetrahydrofuran; methanol / 4 h / 50 °C

5: ammonium chloride; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; water; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;