N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine
CAS No.:1335286-67-3
Molecular Formula:C₂₆H₃₇NO₃Si
Molecular Weight:439.67
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine

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Chemical Property of N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine

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Technology Process of N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine

There total 5 articles about N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 134210-15-4
(2S,3R)-tert-butyl-N-(3-hydroxypent-4-en-2-yl)carbamate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1335286-67-3
N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine

Guidance literature:: With dmap; triethylamine; at 0 - 90 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: C₁₇H₂₃NO₄

: 1335286-67-3
N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / tetrahydrofuran; methanol

2: dmap; triethylamine / 48 h / 0 - 90 °C / Inert atmosphere

With dmap; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: 28875-17-4
(S)-N-(tert-butoxycarbonyl)alanine methyl ester

: 1335286-67-3
N-(tert-butoxycarbonyl)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.1: tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere; Saturated solution

3.1: dmap; triethylamine / 48 h / 0 - 90 °C / Inert atmosphere

With dmap; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2011.08.014