(2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

Base Information

Chemical Name:(2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate
CAS No.:1078641-86-7
Molecular Formula:C₅₅H₅₂FNO₁₃
Molecular Weight:954.015
Hs Code.:

(2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

Synonyms:(2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

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Chemical Property of (2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

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Technology Process of (2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

There total 1 articles about (2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1078641-84-5
(2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-4-oxo-1-{4-[(trimethylsilyl)ethynyl]phenyl}azetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1078641-86-7
(2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: With tetrabutyl ammonium fluoride; at 0 ℃; for 0.5 - 2h;

Reference yield:

: 1078641-86-7
(2S,3S,4R,5R,6R)-2-[4'-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-ethynylphenyl)-4-oxoazetidin-2-yl]-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 108306-61-2
5-Iodothiazole

: 1078641-87-8
(2S,3S,4R,5R,6R)-2-[4'-{(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-4-oxo-1-[4-(1,3-thiazol-5-ylethynyl)phenyl]azetidin-2-yl}-3'-(benzyloxy)biphenyl-3-yl]-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 40 - 100 ℃; for 12.1667 - 24.3333h;