2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

Base Information

Chemical Name:2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate
CAS No.:1426253-68-0
Molecular Formula:C₄₅H₆₃NO₁₁Si
Molecular Weight:822.081
Hs Code.:

2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

Synonyms:2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

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Chemical Property of 2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

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Technology Process of 2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

There total 3 articles about 2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 40608-06-8
levulinic anhydride

: 1426253-67-9
2-[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]-oxy}tetrahydrofuran-2-yl]-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}acetamide

: 1426253-68-0
2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1002/hlca.201200153

Reference yield:

: 634178-89-5
ethyl [(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetate

: 1426253-68-0
2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water; 1,4-dioxane / 20 °C

1.2: Dowex-50 resin (pyridinium form) / 5 h

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 20 °C

3.1: pyridine / 20 °C

With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201200153

Reference yield:

: C₃₄H₄₄O₇Si

: 1426253-68-0
2-{2-[2-({[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(tert-butyl)(dimethyl)silyl]oxy}tetrahydrofuran-2-yl]acetyl}amino)ethoxy]ethoxy}ethyl 4-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 20 °C

2: pyridine / 20 °C

With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1002/hlca.201200153