{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Base Information

Chemical Name:{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester
CAS No.:1620738-95-5
Molecular Formula:C₂₃H₁₈N₂O₃S
Molecular Weight:402.474
Hs Code.:

Synonyms:{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

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Chemical Property of {[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Chemical Property:

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Technology Process of {[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

There total 6 articles about {[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1613219-39-8
7-(4-phenylthiazol-2-yl)-naphthalene-2-carboxylic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1620738-95-5
{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 5159-63-7
7-bromo-naphthalene-2-carboxylic acid methyl ester

: 1620738-95-5
{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

3: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 2: |Suzuki Coupling;

Reference yield:

: 5043-14-1
7-bromonaphthalene-2-carboxylic acid

: 1620738-95-5
{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 18 h / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

4: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium acetate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 3: |Suzuki Coupling;