3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole

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Chemical Name:3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole
CAS No.:94223-65-1
Molecular Formula:C₁₃H₁₅N₃O
Molecular Weight:229.282
Hs Code.:

Synonyms:3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole

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Chemical Property of 3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole

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Technology Process of 3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole

There total 3 articles about 3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 94223-61-7
4-Methoxy-benzoic acid N'-(5-methyl-4,5-dihydro-3H-pyrrol-2-yl)-hydrazide

: 94223-65-1
3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole

Guidance literature:: at 280 ℃; for 0.333333h; under 5 Torr;
DOI:10.1016/S0040-4020(01)96889-9

Reference yield:

: 25877-54-7
methyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl ether

: 94223-65-1
3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi; 2.) 1 N HCl / 1.) THF, HMPA, hexane, -78 deg C - RT, 30 min; 2.) CHCl₃, water, RT, 30 min

2: 54 percent / NaBH₃CN, NH₄OAc / methanol / 4 h / Heating

3: 86 percent / 0.33 h / 280 °C / 5 Torr

With hydrogenchloride; n-butyllithium; ammonium acetate; sodium cyanoborohydride; In methanol;
DOI:10.1016/S0040-4020(01)96889-9

Reference yield:

: 94223-54-8
4-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-butan-2-one

: 94223-65-1
3-(4-Methoxy-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / NaBH₃CN, NH₄OAc / methanol / 4 h / Heating

2: 86 percent / 0.33 h / 280 °C / 5 Torr

With ammonium acetate; sodium cyanoborohydride; In methanol;
DOI:10.1016/S0040-4020(01)96889-9