5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Base Information

Chemical Name:5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile
CAS No.:1266519-73-6
Molecular Formula:C₂₁H₁₁F₂N₅O₂S
Molecular Weight:435.413
Hs Code.:

Synonyms:5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Suppliers and Price of 5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

There total 7 articles about 5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187919-27-2
imidazolidin-4-one trifluoroacetate

: 1266520-50-6
4-(3-cyano-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

: 1266519-73-6
5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1266519-73-6
5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane; dimethyl sulfoxide / 90 °C / Inert atmosphere

2: sodium periodate; ammonium acetate / water; acetone / 20 °C

3: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 20 °C / Reflux

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; acetone;

Reference yield:

: 1266520-42-6
ethyl 4-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylate

: 1266519-73-6
5-{5-(3-cyano-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; potassium acetate; acetic acid / 48 h / 100 °C

2: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 20 °C / Reflux

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; potassium acetate; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water;