Technology Process of 3-benzyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
There total 10 articles about 3-benzyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 70 percent / H2, aq. HCl / Pd(OH)2 / ethanol / 22 h / 50 °C / 2172.02 Torr
2: 89 percent / Et3N / CH2Cl2 / 2 h / 25 °C
3: phosphate buffer, porcine liver esterase / H2O / 27 h / 37 °C
4: TFA / CH2Cl2 / 1.5 h / 40 °C
5: DCC, DIEA, HOBT, DMAP / CH2Cl2 / 20 h / 25 °C
6: 93 percent / DMAP / toluene / 1 h / 60 °C
7: 90 percent / Superhydride / tetrahydrofuran / 2 h / 0 °C
8: Et3SiH, BF3*Et2O / CH2Cl2 / 2 h / -78 °C
With
hydrogenchloride; triethylsilane; porcine liver esterase; dmap; phosphate buffer; boron trifluoride diethyl etherate; hydrogen; lithium triethylborohydride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo980990v
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 99 percent / EtONa, MTBE / ethanol / 1 h / 40 °C
2: 70 percent / H2, aq. HCl / Pd(OH)2 / ethanol / 22 h / 50 °C / 2172.02 Torr
3: 89 percent / Et3N / CH2Cl2 / 2 h / 25 °C
4: phosphate buffer, porcine liver esterase / H2O / 27 h / 37 °C
5: TFA / CH2Cl2 / 1.5 h / 40 °C
6: DCC, DIEA, HOBT, DMAP / CH2Cl2 / 20 h / 25 °C
7: 93 percent / DMAP / toluene / 1 h / 60 °C
8: 90 percent / Superhydride / tetrahydrofuran / 2 h / 0 °C
9: Et3SiH, BF3*Et2O / CH2Cl2 / 2 h / -78 °C
With
hydrogenchloride; triethylsilane; porcine liver esterase; dmap; phosphate buffer; tert-butyl methyl ether; boron trifluoride diethyl etherate; hydrogen; sodium ethanolate; lithium triethylborohydride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo980990v
- Guidance literature:
-
With
triethylsilane; boron trifluoride diethyl etherate;
In
dichloromethane;
at -78 ℃;
for 2h;
DOI:10.1021/jo980990v
