N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide
• CAS No.: 1261245-13-9
• Molecular Formula: C₁₉H₂₃NO₃S
• Molecular Weight: 345.463
• Mol file: 1261245-13-9.mol

Synonyms:N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide

Chemical Property of N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide

There total 1 articles about N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allylmagnesium bromide (2622-05-1) + (S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (206759-70-8) → N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide (1261245-13-9)

Guidance literature:

allylmagnesium bromide; (S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; optical yield given as %ee; diastereoselective reaction;

DOI:10.1002/adsc.201000450

Reference yield: 60.0%

N-((2S,3R)-3-hydroxy-3-phenylhex-5-en-2-yl)-4-methylbenzenesulfonamide (1261245-13-9) → (2S,5S)-2,5-dimethyl-3-phenyl-1-tosyl-2,5-dihydro-1H-pyrrole (1261245-40-2)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 80 ℃; for 15h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201000450

upstream raw materials:

allylmagnesium bromide

(S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide

Downstream raw materials:

(2S,5S)-2,5-dimethyl-3-phenyl-1-tosyl-2,5-dihydro-1H-pyrrole