(R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate
CAS No.:1619261-32-3
Molecular Formula:C₁₈H₂₃F₃INO₄
Molecular Weight:501.285
Hs Code.:

Synonyms:(R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate

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Chemical Property of (R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate

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Technology Process of (R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate

There total 5 articles about (R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1619261-28-7
(R)-3-(tert-butoxycarbonyl)-2,2,2-trifluoro-acetamido-4-(3-methoxyphenyl)butyl 4-methylbenzenesulfonate

: 1619261-32-3
(R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate

Guidance literature:: With sodium iodide; In acetone; at 35 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2014.06.008

Reference yield:

: 128427-10-1,156627-42-8
(S)-2-(tert-butoxycarbonylamino)-1,4-butanediol

: 1619261-32-3
(R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / diethyl ether / 24 h / Reflux; Inert atmosphere

2.1: magnesium / tetrahydrofuran / 0.67 h / Inert atmosphere

2.2: 2.08 h / -40 - -10 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

4.1: sodium iodide / acetone / 12 h / 35 °C / Inert atmosphere

With magnesium; triethylamine; sodium iodide; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; acetone;
DOI:10.1016/j.tet.2014.06.008

Reference yield:

: 1619261-23-2
(S)-tert-butyl-(2-(2-tosyloxy)ethyl)aziridine-1-carboxylate

: 1619261-32-3
(R)-tert-butyl 4-iodo-1-(3-methoxyphenyl)-butan-2-yl(2,2,2-trifluoroacetyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 0.67 h / Inert atmosphere

1.2: 2.08 h / -40 - -10 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium iodide / acetone / 12 h / 35 °C / Inert atmosphere

With magnesium; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.tet.2014.06.008