Technology Process of (S)-1,3-dibenzyl-3-fluoropyrrolidine
There total 8 articles about (S)-1,3-dibenzyl-3-fluoropyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/jo300887u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 8 h / Inert atmosphere; Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo300887u
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere
2.1: palladium on activated charcoal; hydrogen / Inert atmosphere
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Inert atmosphere
4.1: potassium hexamethylsilazane / N,N-dimethyl-formamide / 0.5 h / -60 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere
6.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 8 h / Inert atmosphere; Reflux
7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
7.2: 0 °C / Inert atmosphere
8.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; carbon tetrabromide; diethylamino-sulfur trifluoride; palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo300887u
