1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-
• CAS No.: 320580-76-5
• Molecular Formula: C18H26N2O4
• Molecular Weight: 334.415
• Hs Code.: 29333990
• Mol file: 320580-76-5.mol

Synonyms:1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-;tert-Butyl (3R)-3-[[(benzyloxy)carbonyl]amino]piperidine-1-carboxylate;(R)-tert-butyl 3-(benzyloxycarbonylamino)piperidine-1-carboxylate;(R)-1-Boc-(3-Cbz-aMino)piperidine;1-Boc-(3R)-3-Cbz-aMinopiperidine

Chemical Property of 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-

Chemical Property:

• Refractive Index: 1.545
• Boiling Point: 471.6 °C at 760 mmHg
• Flash Point: 239 °C
• PSA: 67.87000
• Density: 1.156 g/cm³
• LogP: 3.64110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(R)-tert-Butyl3-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-

There total 2 articles about 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

→ tert-butyl (3R)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (320580-76-5,1002360-09-9)

Guidance literature:

Reference yield:

tert-butyl (3R)3-aminopiperidine-1-carboxylate (188111-79-7) + benzyl chloroformate (501-53-1,94274-21-2) → tert-butyl (3R)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (320580-76-5,1002360-09-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2019.126748

Reference yield: 99.0%

tert-butyl (3R)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (320580-76-5,1002360-09-9) → tert-butyl (3R)3-aminopiperidine-1-carboxylate (188111-79-7)

Guidance literature:

Pd-C; In methanol;

upstream raw materials:

tert-butyl (3R)3-aminopiperidine-1-carboxylate

benzyl chloroformate

Downstream raw materials:

tert-butyl (3R)3-aminopiperidine-1-carboxylate