(S)-1-Boc-3-(Hydroxymethyl)Piperidine

Base Information

Chemical Name:(S)-1-Boc-3-(Hydroxymethyl)Piperidine
CAS No.:140695-84-7
Molecular Formula:C11H21NO3
Molecular Weight:215.293
Hs Code.:29333990
European Community (EC) Number:676-064-4
DSSTox Substance ID:DTXSID10363895
Wikidata:Q72449650
Mol file:140695-84-7.mol

Synonyms:140695-84-7;(S)-1-Boc-3-(Hydroxymethyl)Piperidine;(s)-n-boc-3-piperidinemethanol;tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate;(s)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate;(s)-1-boc-3-(hyroxymethyl)piperidine;(S)-1-N-Boc-3-hydroxymethyl-piperidine;(S)-1-N-Boc-3-(hydroxymethyl)piperidine;(S)-1-Boc-3-hydroxymethyl piperidine;MFCD02683203;(S)-N-Boc-Piperdine-3-hydroxymethyl;(s)-n-boc-3-(hyroxymethyl)piperidine;(S)-N-Boc-3-hydroxymethyl piperidine;(s)-3-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester;MFCD02683202;(S)-1-Boc-3-hydroxymethyl-piperidine;tert-butyl (S)-3-(hydroxymethyl)piperidine-1-carboxylate;(R)-1-N-BOC-3-(HYDROXYMETHYL)PIPERIDINE;SCHEMBL1785894;DTXSID10363895;(3S)-3-(Hydroxymethyl)piperidine;AMY18248;BCP26383;CS-M1119;(s)-1-boc-3-hydroxymethylpiperidine;AKOS005258735;AS-35391;EN300-1068251;Q-103002;t-butyl (S)-3-hydroxymethyl-1-piperidinecarboxylate;t-butyl (S)-3-hydroxymethyl-l-piperidinecarboxylate;(s)-n-(tert-butoxycarbonyl)-3-hydroxymethylpiperidine;{(3S)-1-(tert-butoxycarbonyl)-3-piperidyl}-methanol;{(3S)-1-(tert-butoxycarbonyl)-3-piperidyl}methanol;tert-butyl (s)-3-hydroxymethylpiperidine-1-carboxylate;tert-butyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate;tert-butyl(3S)-3-(hydroxymethyl)piperidine-1-carboxylate;(S)-3-hydroxymethyl-piperidine-1-carboxylic acid, tert-butyl ester;1,1-dimethylethyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate

Suppliers and Price of (S)-1-Boc-3-(Hydroxymethyl)Piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Activate Scientific
(S)-N-Boc-3-Piperidinemethanol 95+% ee
1 g
$ 29.00

Activate Scientific
(S)-N-Boc-3-Piperidinemethanol 95+% ee
100 g
$ 845.00

AK Scientific
(S)-1-Boc-3-(hydroxymethyl)piperidine
5g
$ 90.00

Alfa Aesar
(S)-1-Boc-3-(hydroxymethyl)piperidine, 97%
5g
$ 150.00

Alfa Aesar
(S)-1-Boc-3-(hydroxymethyl)piperidine, 97%
1g
$ 38.10

Alichem
(S)-N-Boc-3-Piperidinemethanol
25g
$ 298.59

Alichem
(S)-N-Boc-3-Piperidinemethanol
100g
$ 685.44

Ambeed
(S)-N-Boc-3-Piperidinemethanol 98%
100g
$ 435.00

Ambeed
(S)-N-Boc-3-Piperidinemethanol 98%
250mg
$ 7.00

Ambeed
(S)-N-Boc-3-Piperidinemethanol 98%
10g
$ 56.00

Total 71 raw suppliers

Chemical Property of (S)-1-Boc-3-(Hydroxymethyl)Piperidine

Chemical Property:

Vapor Pressure:6.41E-05mmHg at 25°C
Melting Point:96-98 °C
Refractive Index:1.479
Boiling Point:308 °C at 760 mmHg
PKA:14.93±0.10(Predicted)
Flash Point:140.1 °C
PSA：49.77000
Density:1.059 g/cm³
LogP:1.56370
Storage Temp.:2-8°C
Water Solubility.:Slightly soluble in water.
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:215.15214353
Heavy Atom Count:15
Complexity:222

Purity/Quality:

99%, ^*data from raw suppliers

(S)-N-Boc-3-Piperidinemethanol 95+% ee ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCCC(C1)CO
Isomeric SMILES:CC(C)(C)OC(=O)N1CCC[C@@H](C1)CO
Uses (S)-1-Boc-3-(hydroxymethyl)piperidine is used as pharmaceutical intermediate.

Technology Process of (S)-1-Boc-3-(Hydroxymethyl)Piperidine

There total 65 articles about (S)-1-Boc-3-(Hydroxymethyl)Piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 116574-71-1,140645-19-8,140695-84-7,140695-85-8
tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: (R)-1-Boc-nipecotic acid; With borane-THF; In tetrahydrofuran; at 20 ℃; for 16h;

With sodium hydroxide; water; In tetrahydrofuran; at 0 ℃; for 48h; Heating / reflux;