1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-

Base Information

• Chemical Name: 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-
• CAS No.: 915226-43-6
• Molecular Formula: C11H20 N2 O3
• Molecular Weight: 228.291
• Mol file: 915226-43-6.mol

Synonyms:(R)-1-(tert-Butoxycarbonyl)nipecotamide

Chemical Property of 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-

Chemical Property:

• Boiling Point: 384.4±31.0 °C(Predicted)
• PKA: 16.41±0.20(Predicted)
• PSA: 73.62000
• Density: 1.123±0.06 g/cm3(Predicted)
• LogP: 2.20640
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl3-carbamoylpiperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-

There total 3 articles about 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C14H23NO6 → (R)-tert-butyl 3-carbamoylpiperidine-1-carboxylate (915226-43-6)

Guidance literature:

With ammonia; In chloroform; at 0 - 20 ℃; for 4h;

Reference yield: 93.0%

nipecotamide (4138-26-5,168749-30-2) + di-tert-butyl dicarbonate (24424-99-5) → (R)-tert-butyl 3-carbamoylpiperidine-1-carboxylate (915226-43-6)

Guidance literature:

nipecotamide; With sodium hydroxide; at 30 ℃; for 60h; pH=7; Aqueous phosphate buffer; Enzymatic reaction;

di-tert-butyl dicarbonate; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; pH=10; Product distribution / selectivity;

Reference yield:

(R)-1-Boc-nipecotic acid (163438-09-3) → (R)-tert-butyl 3-carbamoylpiperidine-1-carboxylate (915226-43-6)

Guidance literature:

(R)-1-Boc-nipecotic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 1h;

With ammonia; In water; N,N-dimethyl-formamide; for 2h;

upstream raw materials:

(R)-1-Boc-nipecotic acid

nipecotamide

di-tert-butyl dicarbonate

Downstream raw materials:

(R)-3-cyano-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl (3R)3-aminopiperidine-1-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 915226-43-6 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send