3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide

Base Information

• Chemical Name: 3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide
• CAS No.: 409332-62-3
• Molecular Formula: C₁₆H₁₅N₃O₆S
• Molecular Weight: 377.378
• Mol file: 409332-62-3.mol

Synonyms:3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide

Chemical Property of 3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide

There total 2 articles about 3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-methyl(p-nitroaniline) (100-15-2) + N-phenylsulfonylmalonamic acid (409332-59-8) → 3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide (409332-62-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1023/A:1011648303788

Reference yield:

N-phenylsulfonylmalonamic acid monoethyl ester (409332-58-7) → 3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide (409332-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / aq. KOH / 3 h / 80 °C

2: 63 percent / dicyclohexylcarbodiimide / dioxane

With potassium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1023/A:1011648303788

Reference yield: 62.0%

3-benzenesulfonylamino-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide (409332-62-3) → 1-phenylsulfonyl-N'-methyl-N'-(p-nitrophenyl)-5-hydroxy-1H-1,2,3-triazole-4-carboxamide sodium salt

Guidance literature:

With 4-toluenesulfonyl azide; sodium ethanolate; In ethanol;

DOI:10.1039/b108202g

upstream raw materials:

N-methyl(p-nitroaniline)

N-phenylsulfonylmalonamic acid

N-phenylsulfonylmalonamic acid monoethyl ester

Downstream raw materials:

3-benzenesulfonylamino-2-diazo-N-methyl-N-(4-nitro-phenyl)-3-oxo-propionamide