(2E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

Base Information

• Chemical Name: (2E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid
• CAS No.: 388566-86-7
• Molecular Formula: C₁₉H₂₀O₇
• Molecular Weight: 360.364
• Mol file: 388566-86-7.mol

Synonyms:(E)-3-(3’-hydroxy-4’-methoxyphenyl)-2-(3”,4”,5”-trimethoxyphenyl)-2-propenoic acid

Chemical Property of (2E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

Chemical Property:

• Vapor Pressure: 5.81E-12mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

There total 4 articles about (2E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(E)-3-(3-acetoxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid (39500-10-2) → (E)-3-(3’-hydroxy-4’-methoxyphenyl)-2-(3”,4”,5”-trimethoxyphenyl)-2-propenoic acid (388566-86-7)

Guidance literature:

(E)-3-(3-acetoxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid; With sodium hydroxide; ethanol; water; In 1,4-dioxane; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; ethanol; water;

Reference yield: 80.0%

isovanillin (621-59-0) + 3,4,5-trimethoxyphenyl acetic acid (951-82-6) → (E)-3-(3’-hydroxy-4’-methoxyphenyl)-2-(3”,4”,5”-trimethoxyphenyl)-2-propenoic acid (388566-86-7)

Guidance literature:

With acetic anhydride; triethylamine; at 110 ℃; for 6h; diastereoselective reaction;

DOI:10.1080/00397911.2010.538889

Reference yield:

3,4,5-trimethoxyphenyl acetic acid (951-82-6) → (E)-3-(3’-hydroxy-4’-methoxyphenyl)-2-(3”,4”,5”-trimethoxyphenyl)-2-propenoic acid (388566-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / 24 h / 140 °C

1.2: 20 °C

2.1: potassium carbonate / methanol; water / 20 °C

2.2: 20 °C

With potassium carbonate; triethylamine; In methanol; water; 1.1: Perkin reaction / 1.2: Perkin reaction;

DOI:10.1016/j.bmc.2011.06.017

upstream raw materials:

isovanillin

3,4,5-trimethoxyphenyl acetic acid

(E)-3-(3-acetoxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid

Downstream raw materials:

4β-((E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylamido)-4-deoxypodophyllotoxin

methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoate