C₅₀H₆₈O₇S₂Si

Base Information

• Chemical Name: C₅₀H₆₈O₇S₂Si
• CAS No.: 344315-41-9
• Molecular Formula: C₅₀H₆₈O₇S₂Si
• Molecular Weight: 873.303
• Mol file: 344315-41-9.mol

Synonyms:C₅₀H₆₈O₇S₂Si

Chemical Property of C₅₀H₆₈O₇S₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₆₈O₇S₂Si

There total 22 articles about C₅₀H₆₈O₇S₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C56H82O7S2Si2 (344315-40-8) → C50H68O7S2Si (344315-41-9)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1016/S0040-4039(01)00286-6

Reference yield:

(2S,3S,4R,4aR,6R,7S,8aR)-2-Allyl-3,4-bis-benzyloxy-6-(3,3-dibromo-allyl)-7-(1-ethoxy-ethoxy)-octahydro-pyrano[3,2-b]pyran → C50H68O7S2Si (344315-41-9)

Guidance literature:

Multi-step reaction with 22 steps

1.1: n-BuLi / tetrahydrofuran

2.1: Amberlyst-15E / methanol

3.1: Co₂(CO)8; BF₃*OEt₂ / CH₂Cl₂

3.2: propargyl alcohol / 1,2-dichloro-ethane / 60 °C

4.1: Jones' reagent / acetone

4.2: 88 percent / PdCl₂; CuCl / dimethylformamide; H₂O

5.1: 86 percent / I(collidine)2PF₆- / CH₂Cl₂

6.1: 90 percent / BF₃*OEt₂ / CH₂Cl₂

7.1: DIBAL-H / CH₂Cl₂

8.1: DBU / tetrahydrofuran

9.1: 81 percent / K₂CO₃ / methanol

10.1: 90 percent / BF₃*OEt₂ / CH₂Cl₂

11.1: p-nitro benzoic acid; DEAD; PPh₃ / toluene

11.2: 94 percent / K₂CO₃ / methanol

12.1: PPTS / CH₂Cl₂

13.1: n-BuLi / tetrahydrofuran

14.1: Amberlyst-15E / methanol

15.1: Jones' reagent / acetone

16.1: I(collidine)2PF₆ / CH₂Cl₂

17.1: BF₃*OEt₂ / CH₂Cl₂

18.1: DIBAL-H / CH₂Cl₂

19.1: DBU / tetrahydrofuran

20.1: 69 percent / n-BuLi

21.1: 65 percent / BF₃*OEt₂ / CH₂Cl₂

With n-butyllithium; jones' reagent; dicobalt octacarbonyl; Amberlyst-15E; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; 4.1: Wacker oxidation / 11.1: modified Mitsunobu inversion;

DOI:10.1016/S0040-4039(01)00286-6

Reference yield:

(2S,3S,4R,4aR,5aR,8S,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol (344315-43-1) → C50H68O7S2Si (344315-41-9)

Guidance literature:

Multi-step reaction with 11 steps

1: PPTS / CH₂Cl₂

2: n-BuLi / tetrahydrofuran

3: Amberlyst-15E / methanol

4: Jones' reagent / acetone

5: I(collidine)2PF₆ / CH₂Cl₂

6: BF₃*OEt₂ / CH₂Cl₂

7: DIBAL-H / CH₂Cl₂

8: DBU / tetrahydrofuran

9: 69 percent / n-BuLi

10: 65 percent / BF₃*OEt₂ / CH₂Cl₂

With n-butyllithium; jones' reagent; Amberlyst-15E; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1016/S0040-4039(01)00286-6

upstream raw materials:

C₅₆H₈₂O₇S₂Si₂

(2S,3S,4R,4aR,5aR,8S,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol

(2S,3S,4R,4aR,5aR,8R,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol

2-((2S,3S,4R,4aR,5aR,9R,10aS,11aR)-2-Allyl-3,4-bis-benzyloxy-7-triethylsilanyl-2,3,4,4a,5a,6,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-9-yl)-ethanol

Downstream raw materials:

C₄₁H₄₈O₇S₂