2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride

Base Information

• Chemical Name: 2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride
• CAS No.: 52418-15-2
• Molecular Formula: C₂₈H₂₂NO₅*Cl
• Molecular Weight: 487.939
• Mol file: 52418-15-2.mol

Synonyms:2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride

Chemical Property of 2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride

There total 4 articles about 2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

→ 2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride (52418-15-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 0.25h;

With dmap; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h;

Reference yield: 60.4%

berberrubine chloride (15401-69-1) + cinnamoyl chloride (102-92-1,17082-09-6) → 2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride (52418-15-2)

Guidance literature:

With pyridine; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmcl.2016.08.027

Reference yield:

berberine chloride (633-65-8) → 2,3-methenedioxy-9-cinnamate-10-methoxyprotoberberine chloride (52418-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 190 °C / 20 - 30 Torr

2: pyridine / acetonitrile / 20 °C

With pyridine; In acetonitrile;

DOI:10.1016/j.bmcl.2016.08.027

upstream raw materials:

berberrubine chloride

cinnamoyl chloride

berberine chloride

Cinnamic acid