3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate

Base Information

• Chemical Name: 3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate
• CAS No.: 1383550-72-8
• Molecular Formula: C₃₂H₃₃NO₇
• Molecular Weight: 543.617
• Mol file: 1383550-72-8.mol

Synonyms:3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate

Chemical Property of 3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate

There total 2 articles about 3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + dibenzyl 2-(1-oxoisoindolin-3-yl)malonate → 3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate (1383550-72-8)

Guidance literature:

With TEABF₄; In acetonitrile; at 20 ℃; chemoselective reaction; Electrolysis;

DOI:10.1002/adsc.201200065

Reference yield:

malonic acid dibenzyl ester (15014-25-2) + o-formylbenzonitrile (7468-67-9) → 3-tert-butyl 1,1-dibenzyl 1-(1-oxoisoindolin-3-yl)propane-1,1,3-tricarboxylate (1383550-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: TEABF₄ / acetonitrile / 2.5 h / 20 °C / Electrolysis

2: TEABF₄ / acetonitrile / 20 °C / Electrolysis

With TEABF₄; In acetonitrile; 2: Michael addition;

DOI:10.1002/adsc.201200065

upstream raw materials:

tert-Butyl acrylate

malonic acid dibenzyl ester

o-formylbenzonitrile