2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate

Base Information

• Chemical Name: 2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate
• CAS No.: 1431374-12-7
• Molecular Formula: C₁₆H₁₇NO₇S
• Molecular Weight: 367.379

Synonyms:2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate

Chemical Property of 2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate

Chemical Property:

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Technology Process of 2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate

There total 1 articles about 2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate (99314-44-0) → 2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate (1431374-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 3 h / 78 °C

2: sodium periodate / water; methanol / 8 h / 0 - 20 °C

3: triethylamine / tetrahydrofuran / 4.5 h / 20 °C

With sodium periodate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1021/ml5001504

Reference yield: 79.0%

sulfamethoxazole (723-46-6) + 2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate (1431374-12-7) → 2-(((3-methyloxetan-3-yl)methyl)sulfinyl)ethyl (4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)carbamate (1616892-20-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1021/ml5001504

Reference yield:

4-N-[(4-fluorophenyl)methyl]benzene-1,2,4-triamine (491871-67-1) + 2-{[(3-methyloxetan-3-yl)methyl]sulfinyl}ethyl (1,3-dioxobenzo[c]azolidin-2-yloxy)formate (1431374-12-7) → N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl){2-[(3-methyloxetan-3-yl)methylsulfinyl]ethoxy}carboxamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

upstream raw materials:

(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate

Downstream raw materials:

2-(((3-methyloxetan-3-yl)methyl)sulfinyl)ethyl (4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)carbamate

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