C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine

Base Information

Chemical Name:C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine
CAS No.:1379670-47-9
Molecular Formula:C₂₀H₁₇N₇O
Molecular Weight:371.401
Hs Code.:

Synonyms:C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine

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Chemical Property of C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine

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Technology Process of C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine

There total 3 articles about C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379670-97-9
tert-butyl (2-{N'-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridine-3-carbonyl]hydrazino}-2-oxo-1-phenylethyl)carbamate

: 1379670-47-9
C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; at 100 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1379670-92-4
5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridine-3-carbohydrazide

: 1379670-47-9
C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 14 h / Inert atmosphere

2: Burgess Reagent / tetrahydrofuran / 0.25 h / 100 °C / Microwave irradiation

With 4-methyl-morpholine; Burgess Reagent; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1379671-06-3
2,2,2-tri-chloro-1-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]ethanone

: 1379670-47-9
C-((S)-C-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}-C-phenyl)methylamine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 0.5 h / 20 °C

2: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 14 h / Inert atmosphere

3: Burgess Reagent / tetrahydrofuran / 0.25 h / 100 °C / Microwave irradiation

With 4-methyl-morpholine; Burgess Reagent; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;