trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester

Base Information

Chemical Name:trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester
CAS No.:1319743-52-6
Molecular Formula:C₂₁H₂₅ClN₂O₄S
Molecular Weight:436.96
Hs Code.:

Synonyms:trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester

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Chemical Property of trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester

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Technology Process of trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester

There total 4 articles about trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207529-78-9
5-chloro-N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-2-methylnicotinamide

: 98-59-9
p-toluenesulfonyl chloride

: 1319743-52-6
trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 1092286-30-0
5-chloro-2-methyl-3-pyridinecarboxylic acid

: 1319743-52-6
trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4: pyridine / dichloromethane / 20 °C

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1207529-77-8
(1r,4r)-methyl 4-(5-chloro-2-methylnicotinamido)cyclohexanecarboxylate

: 1319743-52-6
trans-toluene-4-sulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

2: pyridine / dichloromethane / 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;