2,3,4,5-TETRAHYDRO-8-METHOXY-1H-PYRIDO[4,3-B]INDOLE

Base Information

• Chemical Name: 2,3,4,5-TETRAHYDRO-8-METHOXY-1H-PYRIDO[4,3-B]INDOLE
• CAS No.: 126912-70-7
• Molecular Formula: C12H14 N2 O
• Molecular Weight: 202.256
• Hs Code.: 2933990090
• Mol file: 126912-70-7.mol

Synonyms:8-Methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;NSC 167705

Chemical Property of 2,3,4,5-TETRAHYDRO-8-METHOXY-1H-PYRIDO[4,3-B]INDOLE

Chemical Property:

• Vapor Pressure: 3.03E-06mmHg at 25°C
• Boiling Point: 388.6°C at 760 mmHg
• Flash Point: 188.8°C
• PSA: 37.05000
• Density: 1.198g/cm³
• LogP: 2.15100
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

8-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5-TETRAHYDRO-8-METHOXY-1H-PYRIDO[4,3-B]INDOLE

There total 8 articles about 2,3,4,5-TETRAHYDRO-8-METHOXY-1H-PYRIDO[4,3-B]INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

8-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (1186099-85-3) → 8‐methoxy‐2,3,4,5‐tetrahydro‐1H‐pyrido[4,3‐b]indole (126912-70-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

Reference yield: 87.0%

ethyl 8-methoxy-1,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (63277-55-4) → 8‐methoxy‐2,3,4,5‐tetrahydro‐1H‐pyrido[4,3‐b]indole (126912-70-7)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; for 16h; Reflux;

DOI:10.1016/j.bmcl.2009.05.094

Reference yield: 78.0%

→ 8‐methoxy‐2,3,4,5‐tetrahydro‐1H‐pyrido[4,3‐b]indole (126912-70-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 15h; Reflux;

upstream raw materials:

4-piperidone hydrochloride

4-methoxyphenylhydrazine hydrochloride

ethyl 8-methoxy-1,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

piperidin-4-one

Downstream raw materials:

2-(3-[3-fluoro-5-(4-methoxytetrahydro-4H-4-pyranyl)phenoxy]propyl)-8-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

(1R,2R)-N-(1-cyanocyclopropyl)-2-[(8-methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]cyclohexanecarboxamide

ethyl 2-(2-benzoyl-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate

8-methoxy-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

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