3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole

Base Information

• Chemical Name: 3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole
• CAS No.: 1396763-71-5
• Molecular Formula: C₃₄H₂₅Cl₂N
• Molecular Weight: 518.485
• Mol file: 1396763-71-5.mol

Synonyms:3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole

Chemical Property of 3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole

There total 3 articles about 3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C34H27Cl2NO (1396763-48-6) → 3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole (1396763-71-5)

Guidance literature:

With 2,4-dinitrobenzenesulfonic acid; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201502174

Reference yield: 70.0%

C34H27Cl2NO (1396763-48-6) → 3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole (1396763-71-5) + C34H27Cl2NO (1396763-80-6)

Guidance literature:

With (PhO)3PAuCl; silver(I) triflimide; In dichloromethane; at -78 ℃; Inert atmosphere;

DOI:10.1055/s-0031-1290950

Reference yield:

1-methylindole (603-76-9) → 3-(1-(bis(4-chlorophenyl)methylene)-3-cyclopropyl-1H-inden-2-yl)-1-methyl-1H-indole (1396763-71-5) + C34H27Cl2NO (1396763-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / acetonitrile / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: (PhO)3PAuCl; silver(I) triflimide / dichloromethane / -78 °C / Inert atmosphere

With n-butyllithium; (PhO)3PAuCl; toluene-4-sulfonic acid; silver(I) triflimide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;

DOI:10.1055/s-0031-1290950

upstream raw materials:

1-methylindole

C₃₄H₂₇Cl₂NO